Everything about Base Analog totally explained
A
base analog is a chemical that can substitute for a normal
nucleobase in
nucleic acids.
A common example would be
5-bromouracil (5BU), the abnormal base found in the mutagenic nucleotide analog BrdU. When a nucleotide containing 5-bromouracil is incorporated into the DNA, it's most likely to pair with adenine; however, it can spontaneously shift into another
isomer which pairs with a different
nucleobase,
guanine. If this happens during DNA replication, a guanine will be inserted opposite the base analog, and in the next DNA replication, that guanine will pair with a cytosine. This results in a change in one base pair of DNA, specifically a
transition mutation.
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